EFSA final aspartame evaluation as safe

Aspartame and its breakdown products are safe for human consumption at current levels of exposure, EFSA concludes in its first full risk assessment of this sweetener. To carry out its risk assessment, EFSA has undertaken a rigorous review of all available scientific research on aspartame and its breakdown products, including both animal and human studies.


“This opinion represents one of the most comprehensive risk assessments of aspartame ever undertaken. It’s a step forward in strengthening consumer confidence in the scientific underpinning of the EU food safety system and the regulation of food additives”, said the Chair of EFSA’s Panel on Food Additives and Nutrient Sources Added to Foods (ANS Panel), Dr Alicja Mortensen.


Experts of ANS Panel have considered all available information and, following a detailed analysis, have concluded that the current Acceptable Daily Intake (ADI) of 40mg/kg bw/day is protective for the general population. However, in patients suffering from the medical condition phenylketonuria (PKU), the ADI is not applicable, as they require strict adherence to a diet low in


English: aspartame; Asp-Phe methyl ester Deuts...
English: aspartame; Asp-Phe methyl ester Deutsch: Aspartam; Asp-Phe Methylester (Photo credit: Wikipedia)


(an amino acid found in proteins).


Following a thorough review of evidence provided both by animal and human studies, experts have ruled out a potential risk of aspartame causing damage to genes and inducing cancer. EFSA’s experts also concluded that aspartame does not harm the brain, the nervous system or affect behaviour or cognitive function in children or adults. With respect to pregnancy, the Panel noted that there was no risk to the developing fetus from exposure to phenylalanine derived from aspartame at the current ADI (with the exception of women suffering from PKU).


The opinion makes clear that the breakdown products of aspartame (phenylalanine, methanol and aspartic acid) are also naturally present in other foods (for instance, methanol is found in fruit and vegetables). The contribution of breakdown products of aspartame to the overall dietary exposure to these substances is low.


The opinion describes the criteria used to identify the studies relevant for the risk assessment and standards applied to evaluate the scientific evidence. EFSA’s experts examined all uncertainties related to the evaluation of aspartame. The opinion explains how these were addressed in the risk assessment to ensure that potential risks from aspartame were not underestimated.


The comprehensive review carried out by the ANS Panel was made possible following two public calls for data which made available a large body of scientific information, comprising both published and previously unpublished data and studies.


EFSA received over 200 comments during the public consultation on the draft opinion (that took place from 9 January 2013 to 15 February 2013) and all of these were considered. During the consultative phase EFSA also held a hearing with interested parties to discuss its draft opinion and the feedback received from the online public consultation. EFSA’s dialogue with stakeholders revealed that there were important aspects of the draft opinion that needed to be clarified in the final output.


EFSA is also publishing today the comments on the draft opinion received during the public consultation, its responses to the comments received and a statement on two recent publications, one from the US Environmental Protection Agency and the other Gift et al., that were brought to EFSA’s attention after the closure of the public consultation. Neither of these studies alters EFSA’s conclusion on aspartame.



(Source: EFSA Website)


Related articles




Written Q&A to EU Commission – Steviol glycosides/energy reduced jam

Question for written answer E-005732/12 to the Commission Hermann Winkler (PPE) (7 June 2012)
Subject: Regulation (EU) No 1131/2011 amending Annex II of Regulation (EC) No 1333/2008 of the European Parliament and of the Council with regard to steviol glycosides

Commission Regulation (EU) No 1131/2011 dated 11 November 2011 amending Annex II of Regulation (EC) No 1333/2008 of the European Parliament and of the Council with regard to steviol glycosides sets down a list of the food additives permitted for use in foods in the European Union and their conditions for use.

Part E of Annex II of this regulation lists approved foods and conditions for use according to food category. Column 6 of the table contains restrictions/exceptions.

1. Is it the case that the restriction ‘only energy-reduced jams, jellies and marmalades’ under Category C4.2.5.1. ‘Extra jam and extra jelly as defined by Directive 2001/113/EC’ is interpreted to mean that steviol glycoside may only be used in energy-reduced jams, jellies and marmalades and that only for these products, by way of exception, is the use of steviol glycoside permitted?

2. If not, is the restriction interpreted in such a way that steviol glycosides may not be used in energy-reduced jams, jellies and marmalades?
Answer given by Mr Dalli on behalf of the Commission (17 August 2012)
The Commission Regulation referred to by the Honourable Member authorises the use of steviol glycosides in the food Category C4.2.5.1. ‘Extra jam and extra jelly as defined by Directive 2001/113/EC (1)’ as well as in the food Category C4.2.5.1. ‘Jam, jelly and marmalades and sweetened chestnut puree as defined by Directive 2001/113/EC’. In both categories steviol glycosides, expressed as steviol equivalents can be used with a maximum amount of 200 mg/kg, provided that the products are energy reduced. This means that the energy value should be reduced by at least 30% compared with the original food or a similar product.